薬理と治療

Abstract

Background Several clinical trials have investigated the impact of coffee-derived mannooligosaccharides on the reduction of abdominal and visceral fat in various kinds of food products, but no systematic review was conducted. Objective The objective was to perform a systematic review with meta-analysis of randomized controlled trials of coffee-derived mannooligosaccharides to better understand its impact on visceral fat reduction in the healthy overweight adults. Design A systematic literature search of scientific databases and register databases for clinical trials and systematic review was conducted. The main outcome measures were abdominal fat area and visceral fat area measured by computed tomography scan. A random-effects model was used to calculate the standardized mean difference and 95％ CIs as the difference between the mean for the treatment and placebo groups. Standard methods for assessing statistical heterogeneity and publication bias were used. Results Five studies met the inclusion criteria. The use of coffee-derived mannooligosaccharides reduced the abdominal fat area ［standardized mean difference（SMD）: －0.99; 95％ CI:－1.26, －0.72］and visceral fat area［SMD: －0.66; 95％ CI: －0.92, －0.40］ No heterogeneity or publication bias was observed in the meta-analysis. Conclusion Coffee-derived mannooligosaccharides might beneficially affect visceral fat in the healthy overweight adults.