薬理と治療

Abstract

Objectives The aim of this study was to clarify whether long time ingestion of fermented milk containing SC-2 lactic acid bacteria, collagen hydrolysates and sphingomyelin increase minimal erythema dose（MED）and skin colors after ultraviolet（UV）radiation in healthy human subjects. Methods A randomized, double -blind, placebo-controlled study was carried out for 70 Japanese women. Subjects ingested the active drink（fermented milk containing SC-2 lactic acid bacteria, collagen hydrolysates, and sphingomyelin）or the placebo drink（skim milk）for 42 days. MED and skin colors were analyzed before and after the ingestion of test drink. Results The change of MED before and after the ingestion was significantly increased in the group fed active drink as compared with the group fed placebo drink in Skin phototypeⅡ subjects, although the change of MED was not different between the groups in Skin phototype Ⅲ subjects. The change of skin colors（delta a＊ and delta L＊ ）was not different between the groups. Conclusions These results suggested that long time ingestion of fermented milk containing SC-2 lactic acid bacteria, collagen hydrolysates, and sphingomyelin increased MED in subjects whose skin caused moderate sunburn, and sun turn after UV radiation.