薬理と治療

Abstract

Objective The study aimed to verify that ingestion of a dietary supplement containing gymnemic acid, mulberry leaf extract, green tea extract, chitosan, kidney bean extract, and Kaempferia parviflora extract would reduce the postprandial blood glucose level of subjects. Methods A randomized, double-blind, placebo-controlled, cross-over study was conducted for 37 participants aged 22 to 63 years whose postprandial blood glucose levels increased more than 140 mg╱dL, ingested the dietary supplement containing 9.4 mg of gymnemic acid, 200 mg of mulberry leaf extract, 200 mg of green tea extract, 100 mg of chitosan, 4.8 mg of kidney bean extract, and 150 mg of Kaempferia parviflora extract or placebo with 200 g of rice as a test diet. The blood glucose and insulin levels were measured before and 30, 60, 90, and 120 minutes after the intake of a test diet, and compared with the changes between placebo and the dietary supplement. Results Intake of the dietary supplement was significantly suppressed the delta AUC（area under the curve）values of postprandial blood glucose and insulin levels after ingestion of a test diet（P＜0.05）. We also observed significant suppression of the elevation of postprandial blood glucose levels after ingestion of a test diet by intake of the dietary supplement（P＜0.05）.Conclusions These results suggest the dietary supplement containing 9.4 mg of gymnemic acid, 200 mg of mulberry leaf extract, 200 mg of green tea extract, 100 mg of chitosan, 4.8 mg of kidney bean extract, and 150 mg of Kaempferia parviflora extract suppresses the elevation of postprandial glucose level.