薬理と治療

Abstract

Objective The study aimed to verify that ingestion of a dietary supplement containing gymnemic acid, chitosan, green tea extract, mulberry leaf extract, kidney bean extract, and Kaempferia parviflora extract would reduce the postprandial serum triglyceride level of subjects. Methods A randomized, double-blind, placebo-controlled, cross-over study was conducted for 60 participants whose fasting serum triglyceride levels were 34 mg╱dL to 193 mg╱dL, ingested the dietary supplement containing 9.4 mg of gymnemic acid, 100 mg of chitosan, 200mg of green tea extract, 200 mg of mulberry leaf extract, 4.8 mg of kidney bean extract, and 150 mg of Kaempferia parviflora extract or placebo with a high fat mea（l 40.0 g fat）. The serum triglyceride level and remnant-like lipoprotein particle cholesterol（RLP-C）level were determined before and 2, 3, 4, 6 hours（hr）after a high fat meal ingestion. Results Intake of the dietary supplement was significantly suppressed the postprandial increase in the serum triglyceride level compared to that in the placebo group. The difference was significant at 2, 3, 4, and 6 hr following ingestion（P＜0.05）. This change was accompanied by the difference in the delta area under the curve（AUC）for serum triglyceride levels （mean±SE: 552.3±33.8 mg・h╱dL for the dietary supplement intake vs. 658.4 ±47.9 mg・h╱dL for the placebo intake; P＜0.01）. We also observed significant suppression of the elevation of postprandial RLP-C level（AUC for delta RLP-C: 22.17±1.70 mg╱dL for the dietary supplement intake vs. 27.39±2.31 mg╱dL for the placebo intake; P＜0.01）. Conclusions These results suggest the dietary supplement containing 9.4 mg of gymnemic acid, 100 mg of chitosan, 200mg of green tea extract, 200 mg of mulberry leaf extract, 4.8 mg of kidney been extract, and 150 mg of Kaempferia parviflora extract suppresses the elevation of postprandial serum triglyceride level and RLP-C level in healthy subjects or subject with moderately high fasting triglyceride levels.