薬理と治療

Abstract

Objective We have previously cleared that apple polyphenols beverage consumption reduces weight and body fat in obese subjects1）. In this study we performed a subanalysis for subject whose BMI is over 23 and less than 30 to evaluate effect to reduce body fat. We also performed a subanalysis for BMI or body fat. Methods This study was a randomized, double-blind, placebo-controlled, parallel-group study. Japanese males and females were divided into three groups; group drinking beverage with apple polyphenols（600 mg╱340 g）or group drinking beverage with apple polyphenols （300 mg╱340 g）or group drinking beverage without apple polyphenols. Subjects were given regular amount of beverage （340g）a day for 12weeks. Subjects of the previous report whose BMI was over 23 and less than 30 were selected and a subanalysis was performed for weight, body fat percentage, and body fat area with CT scanning. Further a subanalysis for BMI（high normal subjects：23≲BMI＜25 or classⅠ obese subjects：25≲BMI＜30）or visceral fat area （VFA）（VFA＜100 cm2 or 100 cm2≲VFA）was performed. Results In high normal subjects, VFA was significantly reduced in the group drinking beverage with apple polyphenols（600 mg╱day）comparing with that of the baseline at Week 12 and wasnʼt significantly changed in the placebo group. In classⅠ obese subjects, VFA was significantly reduced in the group drinking beverage with apple polyphenols（600 mg╱day）comparing with that of the placebo group at Week 12. Conclusion It was shown that drinking beverage with apple polyphenols（600 mg╱day）was effective on the reduction of visceral fat for high normal and classⅠ obese subjects.