薬理と治療

Abstract

Background Kyushin capsule F is an over the counter drug for amelioration of a palpitation, short of bless and as a restorative. These symptoms are included typical symptoms of menopause. Objectives The aim of this study was to investigate an efficacy and safety of the Kyushin capsule F on aged women experiencing mild to moderate menopausal syndrome. Methods An open trial study was conducted with female volunteers have typical symptom of menopause and some indefinite complains related cardiovascular medicine. Subjects（20 subjects: aged 40 to 62）were orally received 3 capsules Kyushin capsule F daily for 4 weeks, and recorded a score of complaints, in addition, the simplified menopausal index, the POMS test, an autonomic nervous function test, and laboratory examination were conducted. Results Kyushin capsule F showed the significant ameliorating effect in the score of indefinite complaints, simplified menopausal index, and POMS test. No adverse effect was observed during this study. Conclusion These findings suggest that Kyushin capsule F is safe, has a potential for effectiveness on the indefinite complaints related insufficient blood circulation, autonomic nerve dysregulation and mood malaise in aged women have mild to moderate menopausal syndrome. Further investigation with more subjects and placebo or reference controlled studies should be needed.