薬理と治療

Abstract

Objectives The aim of this study was to investigate the effect of molecular hydrogen-infused water intake on the status of obesity in adult subjects whose body mass index（BMI） is less than 30. Methods A double-blind, placebo-controlled, parallel-group study was conducted with 62 healthy subjects（aged from 20 to 64）, who were allocated to placebo drink group（group P, n＝31）or active drink group（group A, n＝31）. Subjects consumed either placebo drink or active drink（molecular hydrogen-infused water; containing 0.64 mg of molecular hydrogen per daily dose, 500 mL）for 12 weeks. Changes in body mass index （ΔBMI）, abdominal visceral and subcutaneous fat area（ΔvFA and ΔscFA, respectively）, and serum lipids and oxidative stress markers were compared between the two groups by unpaired t-test. Results All of the subjects completed the study, and data for these subjects were analyzed for efficacy and safety. ΔBMI in group A was significantly lower than that in group P at week 4（－0.13 ±0.10 vs. ＋0.21±0.11, P＜0.05）and week 8（－0.14±0.11 vs. ＋0.18±0.11, P＜0.05）. Further, ΔscFA in females in group A was significantly smaller（－13.14 ±5.32 cm2 vs. ＋5.37±6.71 cm2, P＜0.05）compared to that in group P. Significantly reduced values for ΔBMI, ΔscFA, and ΔvFA（at week 12）were observed in group A in comparison to group P in a stratified analysis performed with subjects whose serum diacron-reactive oxygen metabolites （one of the oxidative stress markers）were higher than the average. No adverse events associated with the intake of hydrogen-infused water were observed during this study. Conclusions Our investigation suggests that intake of hydrogen-infused water improves the status of obesity.