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薬理と治療
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アカシア樹皮抽出物のヒトでの過剰摂取における安全性評価試験―プラセボ対照二重盲検無作為化並行群間比較試験―
JPY
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ライフサイエンス出版
Abstract
Objective Acacia mearnsii bark contains acacia polyphenols, which are a complex mixture of proanthocyanidins mainly composed of 5︱deoxycatechin units. An aim of study was to evaluate the safety of acacia bark extract（Acacia Polyphenol）in humans. Methods An overdose study was conducted with volunteers who were randomized to the acacia group（1875 mg of acacia bark extract daily for 4 weeks, n＝14, 48.7±12.3 years）, or the placebo group（n＝15, 48.1±9.7 years）in a double︱blind, parallel study. Results The study showed that no abnormality in the medical questions, vital sign, hematological analyses, blood biochemistry tests, urinary analyses. The result of this study showed that there were no adverse side effects. Conclusion The safety and acceptability of acacia bark extract, mainly composed of proanthocyanidins, in humans is exceedingly high.
