薬理と治療

Abstract

Self-induced lifestyle problems, such as stress, negative emotions, or irregular sleep-wake schedule, cause sleep disturbance. Lactoferrin has been reported to improve sleep quality and enteric environment in rats and humans. Our previous randomized placebo-controlled double-blind trial has shown that lactoferrin supplementation for 4 weeks could increase immunoglobulin A（IgA）secretion and improve sleep quality, daily mood, and enteric environment in sixty participants. In the present study, lactoferrin supplementation was evaluated in poor sleepers（total mood disturbance scores were more than the median）. In all, thirty-one participants took LLF （liposomal lactoferrin: lactoferrin 270 mg╱d）or a placebo for four weeks. Significant improvement in OSA sleep inventory for middle age and aged（OSA-MA）“sleepiness and fatigue on rising”and“initiation and maintenance of sleep”, Profile of Mood States“depression-dejection”, and stool consistency were found in the LLF group but not in the placebo group. The changes in subjective sleep quality had a significant linear correlation with the changes in the enteric environment. In conclusion, four-week lactoferrin supplementation may improve subjective sleepiness and fatigue on rising, nighttime sleep quality, daily depressed mood, and stool consistency.