薬理と治療

Abstract

Objectives The aim of this study was to evaluate the efficacy of water-extracted amla-containing supplement on recovery of body surface temperature and blood flow following cold water stress in female subjects sensitive to cold temperature. Methods Volunteers（32 subjects）were enrolled in a randomized, double-blind, placebo-controlled, crossover study. Subjects ingested amla extract-containing supplement（0.8 mg corilagin）or a placebo supplement. Recovery of body surface temperature and blood flow following cold water stress was compared 2 hours following supplement ingestion. Results As a result of validation on crossover design, the effect of testing period was not statistically significant, although the effect of the order had a tendency to differ. The intake of amla extract-containing test supplement resulted in a significant increase in body surface temperature and blood flow compared to the placebo group when evaluated in test period I. Conclusions The ingestion of amla extract-containing supplement accelerated recovery of body surface temperature and blood flow following cold water stress. This result suggested that the amla water extract may be a useful supplement for subjects who ordinarily feel “hie”