薬理と治療

Abstract

Objectives The aim of the present study was to investigate an effect of food containing rare sugar syrup（RSS）and sugar as sweetener compared to sugar alone on blood glucose response in healthy adult humans with various type of foods such as drink, solid food and liquid food. Method Three randomized, single blind, placebo-controlled and crossover trials were conducted. Subjects participated in 2 treatments using a placebo food containing sucrose alone as sweetener and a test food replacing half amount of sucrose by RSS in drink（n＝6）and solid food（n＝14）trials. There were 3 treatments for liquid food trial（n＝10）replacing sucrose by RSS at different ratios, i. e. 0％ for placebo, 30％ and 50％ of RSS for test foods. Blood collections were conducted 5 time-points before and after ingestion of foods to check the blood glucose and insulin levels. Result The results of both drink and solid food trials showed significant reductions in incremental area under the curve（iAUC）by each test food compared to the sucrose control. Significant reductions in iAUC were also found in liquid food trial in both test food groups. All test foods partially replaced sucrose by RSS, including drink, solid food and liquid food, showed significant reductions in iAUC of postprandial blood glucose compared to the sucrose control. There was no significant change found in insulin levels. Conclusion These results suggest that a partial replacement of sucrose by RSS in food and beverage would elicit a significant lower glycemic response than sucrose alone in humans.