薬理と治療

Abstract

Objectives This studyʼs objective was to examine the effects of a purple sweet potato（PSP） beverage rich in acylated anthocyanins on serum hepatic biomarkers in healthy Japanese men. Methods We previously published the results of a clinical study on this PSP beverage. In this secondary analysis, we re -examined the previous results of subjects with serum hepatic biomarker levels below the“reference value for which examination is recommended”, which is described in the“Standard Medical Checkup╱Insurance Guidance Program ［Revised Version］” published by the Ministry of Health, Labour and Welfare. Results The PSP group had significantly lower GOT values than the placebo group at 2 and 4 weeks after ingestion（P＝0.014 and 0.013, respectively）. In addition, the PSP group had significantly lower GPT values than the placebo group at 4 weeks after ingestion（P＝0.019）, and significantly lower γ-GTP values than the placebo group at 2, 6, and 8 weeks after ingestion（P＝0.039, 0.025, and 0.002, respectively）. Conclusions These results are consistent with those in the previous report, and showed that the PSP beverage improved liver function in healthy men with serum hepatic biomarker levels below the“reference value for which examination is recommended”.