薬理と治療

Abstract

Objective YASOUKOUSO, derived from multiple wild plants and fruits, is expected to improve blood flow rate. We investigated the blood flow rate following intake of a test beverage for 4 weeks with continuous administration in a randomized, double-blind, placebo-controlled, parallel-group study. Methods Forty-four healthy Japanese subjects satisfied the selection criteria, and they were randomly allocated into two groups（22 subjects per group）. The subjects drank a cup of either YASOUKOUSO or the placebo beverage（25 mL）once per day at optional timing for 4 weeks. Blood flow perfusion and blood capillary were measured, and the safety of the test beverage was also evaluated. Results Two subjects dropped out in the study and therefore, were excluded from the analysis. Of the 42 subjects included in the analysis, 21 were in the YASOUKOUSO group（5 male and 16 female, mean age±SD, 48.2±7.7 years）and 21 subjects were in the placebo group（5 male and 16 female, mean age±SD, 48.0±8.2 years）. After the intake of the test beverage, the blood flow perfusion rate significantly increased in the YASOUKOUSO group compared with that in the placebo group（P＝0.039）. No safety concerns were observed during the intervention period. Conclusions The result suggests that the intake of YASOUKOUSO improves the blood flow. In addition, the intake of YASOUKOUSO was safe under the conditions of this study. Trial Registration UMIN-CTR: UMIN000028182