薬理と治療

Abstract

Objectives The aim of this study was to investigate the effect of oral intake of Amazake on skin in healthy women. Methods This randomized, double-blind, placebo-controlled parallel-group comparison study included 40 premenopausal healthy women（aged 35-45 years）with concerns regarding their skin condition. The women were randomly divided into 2 groups, and 2 packs per day of the test product（Amazake）or the control product（placebo drink）were administered for 5 weeks. Five weeks later, pore-sagging, viscoelasticity, brown spots, skin redness and sebum quantity were evaluated. Results Comparison between pre- and post-trial features after 5 weeks showed that pore-sagging was significantly decreased in the Amazake group. A rate of pore︱sagging change was significantly ameriolated in Amazake group compared that in placebo group. Related to elasticity, a significant increase of the R7values at 5 weeks after intervention of Amazake compared that in pre-intervention was found. Change amount of Brown spots and skin redness were significantly improved in the Amazake group. Sebum quantity was significantly decreased in ingested Amazake comparison between pre- and 5 weeks after intervention. Conclusions These results suggest that oral ingestion of Amazake positively affects pore-sagging, brown spots and redness of the skin in healthy adult women（. UMIN-CTR000025663）