薬理と治療

Abstract

Objective The present study aimed to verify that the ingestion of tea flower extract, mulberry leaf extract, and chitosan would reduce the postprandial blood glucose and triglyceride level of the healthy subjects. Methods In Trial 1, 40 subjects whose fasting blood glucose level were less than 125 mg╱dL, postprandial blood glucose level at 30 min or 60 min were more than 140 mg╱dL and postprandial blood glucose level at 120 min were less than 200 mg╱dL were enrolled in randomized, double-blind, placebo-controlled, cross over study. They ate 200 g of rice after ingesting of 150 mL water with tablets containing tea flower extract, mulberry leaf extract, and chitosan （test tablets）or placebo tablets. The blood glucose level was measured before and 30, 60, 90, 120 minutes after the intake of rice. In Trial 2, 50 subjects whose fasting blood triglyceride level were less than 200 mg╱dL were enrolled in randomized, double-blind, placebo-controlled, cross over study. They ate a bowl of soup containing 40.0 g of total fat （high fat diet） after ingesting of 150 mL water with the test tablets or placebo. The blood triglyceride level was measured before and 2, 3, 4, 6 hours after the intake of high fat diet. Results Ingestion of the test tablets suppressed the AUC（area under the curve）values of postprandial blood glucose level（Trial 1）and the AUC values of postprandial blood triglyceride level（Trial 2）. Conclusions These results suggest that ingestion of tea flower extract, mulberry leaf extract, and chitosan reduce the postprandial blood glucose and triglyceride level. （UMIN ID:UMIN000032752, UMIN000032754）