薬理と治療

Abstract

Objectives The aim of this study was to evaluate the effect of drink containing Lactobacillus paracasei subsp. paracasei NY1301 on defecation（fecal properties and fecal microflora）. Methods One hundred nineteen healthy volunteers with a tendency for constipation were enrolled in a placebo-controlled, randomized, double-blind, parallel-group study. The volunteers were given test drink ontaining forty billion of Lactobacillus paracasei subsp. paracasei NY1301 or a placebo daily for two weeks. Results Compared to before ingestion period, defecation frequency and fecal properties were significantly improved throughout ingestion period by test drink and placebo. The fecal analysis showed that Lactobacillus sp. and B. longum subsp. longum were significantly increased after ingestion of test drink. Conclusions In conclusion, the distinct effect of drink containing Lactobacillus paracasei subsp. paracasei NY1301 on defecation were observed, and fecal analysis indicate that Lactobacillus paracasei subsp. paracasei NY1301 improve the intestinal environment by increase of Lactobacillus sp. and B. longum subsp. longum. It was expected sufficiently about improving the intestinal environment, bowel movement and fecal property（. UMIN000031414）