薬理と治療

Abstract

Objectives The aim of this study is to evaluate for the effects of the supplement containing Andrographis paniculata（Burm. f.）Nees extract on subjects with high normal liver function. Methods A randomized, double-blind, placebo-controlled, parallel-group study was conducted. Forty-four subjects aged 20 to 64 years whose ALT levels were top 44 out of the participants applying to the criteria （both ALT and AST less than 50 U╱L）were randomly divided into two groups: the test product（supplement containing Andrographis paniculata extract）group and control product（placebo）group. The subjects were given each product for 12 wk. Daily intake of the test product was contained 700 mg of Andrographis paniculata extract. Markers of liver function, LPO and the safety were evaluated. Results Compared with placebo group, the test product group did not show any significant improvement on liver function and LPO. Conversely, markers of liver function indicated slight increase. Side effects related to the test product group were not confirmed in this study. Conclusions These results suggested that consecutive intake of 700 mg╱day of Andrographis paniculate extract for 12weeks had no positive effect on high normal liver function. （UMIN ID：UMIN000027495）