薬理と治療

Abstract

Objective　In this study, we evaluated the effects of a composite supplement containing curcumin, ferulic acid, and soybean-derived phosphatidylserine on cognitive function in healthy middle-aged and senior adults. Methods　A randomized, double-blind, placebo-controlled, parallel-group study was conducted for 40 healthy Japanese subjects aged 50 to 69 years with memory complaints, ingested the dietary supplement containing 40 mg of curcumin, 200 mg of ferulic acid, and 25 mg of soybean-derived phosphatidylserine or placebo for 20 weeks. Cognitive function and quality of life were measured at baseline, after 6 weeks, 12 weeks, and 20 weeks of supplementation. Results　Regarding subjective symptoms of cognitive function, significant improvement of memory and attention was found in the active group compared to the placebo group after 20 weeks. In the subgroup analysis with lower cognitive function（≤25 MoCA-J scores）, significant improvement of Verbal Paired Associates-no semantic relation test at 20 weeks, both hands test of Purdue Pegboard at 12 weeks, and step1 and step2 subtests of Stroop Test at 12 weeks was found in the active group compared to the placebo group. No side effects induced the composite supplement were observed during the study. Conclusion　These results suggest that the ingestion of the composite supplement improves cognitive function including memory, attention, and judgment in healthy middle-aged and senior adults.（ UMIN- CTR ID: UMIN000029559）