薬理と治療

Abstract

Objective　The aim of the present study was to investigate the effect of soy-derived peptide containing chewable tablet on a physiological and psychological response in human, a randomized, double-blind, placebo-controlled crossover study were conducted. Methods　In this crossover trial, healthy volunteers were allocated into two groups, Group A and Group B. Eight（8）subjects in the Group A, the test article（chewable tablet containing 200 mg of soy-derived peptide）were administered once in the 1st phase and placebo tablet were administered once in 2nd phase after ＞one week washout period. Similarly, seven（7） volunteers in the Group B were administered in reverse order with the same washout period. In the administration phase, amylase activity of saliva, blood pressure and pulse rate were determined, and two questionnaires（POMS and STAI）were filled out before administration. Fifteen minutes for a resting period after administration, subjects carried out Kraepelinʼs arithmetic test for another fifteen minutes. During thirty minutes of the resting and calculating periods, the electrocardiogram monitoring were conducted for each subject. After the electrocardiogram examination, another set of test （amylase activity, blood pressure, pulse rate and questionnaires） were carried out. Results and Conclusions　As the result, the POMS score of“Depression-Dejection”item in the test article group was significantly reduced as compared with the placebo group, suggesting that the soy-derived peptide containing chewable tablet may ameliorate a feeling of depression and anxiety as psychological effect.