薬理と治療

Abstract

Objective　Our aim was to determine the effects of a single-dose of nattokinase administration on activity of natural killer（NK）cells, blood pressure, and body temperature in healthy male Japanese. Methods　A randomized, double-blind, placebo-controlled crossover nattokinase intervention study was carried out in 10 healthy males（30.2±7.6 yr）. Following the baseline blood draw and measurements, each subject was randomized to receive either a single-dose of 4000 FU nattokinase（NSK-SD, Japan Bio Science Laboratory Co., Ltd）or placebo with subsequent crossover of the groups. Subjects donated blood samples at 6 hours following administration for analysis of activity of NK cells. Blood pressure and body temperature measurements were also performed. Results　There was a significant interaction of activity of NK cells between administration and time（P＝0.013）. The percent change in the activity of NK cells before and after 6 hours of administration was also different between nattokinase and placebo groups（P＝0.013）. The change in tympanic temperature tended to increase after 6 hours of nattokinase administration compared with placebo（P＝0.09）. Alternatively, no change was found in blood pressure before and after nattokinase administration in healthy individuals. Conclusion　A single-dose of nattokinase administration appears enhancing activity of NK cells.