薬理と治療

Abstract

Objectives　This study aimed to investigate the effects of psyllium husk ingestion on the suppression of postprandial blood glucose elevation in healthy adults. Methods A randomized, double-blinded, placebo-controlled, crossover study was conducted. A total of 50 subjects ingested psyllium husk or placebo（without psyllium husk）and consumed 300 g of salted rice balls as a high-carbohydrate meal（106.5 g of carbohydrate）15 min after ingestion of psyllium husk or placebo. Blood samples were collected before and 30, 60, 90, and 120 min after meal to measure blood glucose and insulin levels. Results　Psyllium husk ingestion significantly suppressed the change in blood glucose levels at 30 min postprandially（P＜0.001）; it significantly suppressed the area under the curve （AUC0-120 min）and incremental area under the curve（iAUC0-120 min）from 0 to 120 min postprandial（P＜0.05）. In addition, psyllium husk ingestion significantly suppressed the change in insulin levels at 30 and 60 min postprandial（30 min, P＜0.001; 60 min, P＜0.05）, the AUC0-120 min and iAUC0-120 min were also significantly low（P＜0.01）. Conclusions　These results confirm that psyllium husk ingestion suppresses the postprandial elevation in blood glucose and insulin levels（. UMIN000035336）