薬理と治療

Abstract

Objectives　The major soybean protein β-conglycinin confers several human health benefits, one of them being improved lipid metabolism. In the present study, we evaluated the effects of processed foods containing β-conglycinin-rich soybean （Nanahomare）on postprandial serum triglyceride（TG）levels in healthy subjects in a clinical trial（UMIN000012031）. Methods　Twenty-four healthy adults participated in this randomized, double-blinded, placebo-controlled, crossover trial. The subjects ingested either test food（containing β-conglycinin-rich soybean）or placebo food after overnight fasting. Blood samples were collected from subjects before ingestion and at 2, 3, 4, 5, and 6 h after ingestion to determine TG levels and other parameters. Results　After ingesting active test food, the area under the curve（AUC0-6h）for triglycerides was significantly decreased. Furthermore, the AUC0-6h for remnant-like particle cholesterol was decreased by the ingestion of active test food. No adverse events were observed during the trial. Conclusions　These results indicated that processed foods containing β-conglycinin-rich soybean can control postprandial serum triglyceride levels.