薬理と治療

Abstract

Objectives　The aim of this study was to evaluate the effect of protease-digested Royal Jelly （pRJ）supplementation on skin conditions and assess its safety. Methods 　A randomized, double-blind, placebo-controlled, parallel-group comparison study was conducted in healthy Japanese men and women. They were administered either pRJ or placebo orally for 12 weeks. The level of skin stratum corneum hydration, trans-epidermal water loss, elasticity, pore conditions, pigmentation and wrinkle were measured. A safety assessment was also performed by blood test, urinary test and interview with a medical doctor. Results　The data obtained from 79 volunteers were analyzed. The skin stratum corneum hydration of arm, pore conditions of face and pigmentation level of face in pRJ group was significantly improved compared with placebo group. Any serious adverse events were not observed during the study period. Conclusions　These results suggested that pRJ supplementation positively and safely improved skin conditions（stratum corneum hydration, pore conditions and pigmentation）in healthy Japanese adults. （UMIN-CTR000034539）