薬理と治療

Abstract

Objectives　The effect of oral probiotic Lactobacillus salivarius TI2711 strain（LS1） on gingiva was examined in healthy adults. Methods　Randomized for humans with stable periodontal tissue（probing depth（PD）of 4 mm or more is 10％ or less, bleeding on probing（BOP）is 10％ or less）In one group, one group received 840 million tablet confections per LS1 and the other group took placebo tablet confections once a day before going to bed. The clinical symptom（BOP, PCR: plaque control record, PD）were measured before the start of administration, 4 weeks, 8 weeks, 12 weeks after the start of administration, and 4 weeks after administration. Results BOP was significantly different between the LS1 group（n＝15）and the placebo group（n＝14）at 12 weeks of administration. In addition, PCR decreased in the LS1 group, but increased in the placebo group, showing a significant difference at 12 weeks. Conclusions　LS1 tablet confection maintained healthy gingiva for adults with healthy periodontal tissue compared to placebo tablet confection. （UMIN000032609）