薬理と治療

Abstract

Background　The effects of ceramides on skin hydration have been well known, but an improvements in quality is still required. We successfully developed a system that produces phytosphingosine from soy sauce lees, which is a main structure of ceramide AP. Objectives　The aim of the present study was to assess the efficacy of tablets containing 2 mg of the phytosphingosine compared with the placebo over 12 week period on skin-moisturizing, using trans epidermal water loss（TEWL）scores as the primary endpoint. Methods We conducted a clinical parallel, double-blind, placebo-controlled trial study to assess the efficacy of the phytosphingosine on skin-moisturizing. 41 healthy adults were divided by age, gender and body mass index（BMI）at baseline, into the ceramides extract group, in which the subjects consumed the tablets containing 2 mg of the phytosphingosine, and the placebo group, in which the subjects consumed a placebo tablets. Results　At week 12, the improvement of score from baseline（week 0）in TEWL score was observed only in the ceramides extract group（P＝0.005）. A significant interaction（group× week）in TEWL score was also observed（P＝0.012）. Conclusions　The study indicated that the oral use of tablets containing 2 mg phytosphingosine improve the skin-moisturizing in healthy adults. （UMIN000029690）