薬理と治療

Abstract

Objectives　To verify the effects of the consumption of capsules containing Allium victorialis subsp. platyphyllum extract on the body temperature of healthy Japanese subjects. Methods　Fifty-eight Japanese adults whose basal body temperature （BBT）on awakening was 35.6℃-36.5℃ participated in the present study. Subjects were randomized into groups receiving Allium victorialis subsp. platyphyllum（AVP group）or placebo（n＝29 per group）using a computerized random number generator and accordingly took two capsules containing AVP or placebo per day for four weeks. BBT on awakening was evaluated as the primary outcome. Palmar skin surface temperature and subjective symptoms were evaluated as secondary outcomes. The palmar skin temperature was evaluated using a 1-minute cold water load. Results　There were 27 subjects in each group. The AVP group had a significantly higher BBT on awakening than the placebo group after 4 weeks of treatment, and it also had a higher change in BBT on awakening after 4 weeks compared with the values at the baseline. The AVP group also showed marginally significant improvement in subjective symptoms of the heat experienced by the cold in the body before the cold water load compared with the placebo group after 4 weeks of treatment, and it also showed an improved change in the symptoms after 4 weeks of treatment compared with before treatment. No adverse effects were reported. Conclusions　The ingestion of AVP extract for 4 weeks increased BBT, confirming a tendency of this treatment to relieve the chilliness of the body.( UMIN000036209） Foundation　YASOUKOUSO Co., Ltd.