薬理と治療

Abstract

Objectives　A research of an intake of supplements containing Lactobacillus plantarum PIC-NBN22（PIC-NBN22）and Fructo-oligosaccharides（FOS）was performed, and the change of human body fat mass was analyzed. Methods　A randomized, double-blind, placebo-controlled, parallel-group trail was performed. 50 Japanese subjects aged from 30 to 65, with a Body Mass Index（BMI）of 23-30 were randomly divided into two groups（the test group＝26, the placebo group＝24）and provided test food（containing PIC-NBN22（2.0×108 cells/day）and FOS（1.5 g/day））or placebo food for once in a day throughout 12 weeks. Results　After the supplements intake of 12 weeks, there wasnʼt a significant change between the two groups. However, in the comparison except for individuals with obesity（both BMI≳25 and visceral fat area≳100 cm2）, the test group showed a significant decrease in BMI and body weight. Furthermore, the area value of abdominal body fat significantly decreased in the test group（the test group: Δ＝－16.2±6.4, the placebo group: Δ＝1.9±6.0, P＝0.048）. Conclusions　In the present study, it indicated that the supplementation of PIC-NBN22 and FOS could have a reduction effect on abdominal fat mass to Japanese who have a tendency to obesity. Trial registration UMIN-CTR：UMIN000032404