薬理と治療

Abstract

Objectives and Methods　The aim of evaluating the effect of intake of Lactobacillus plantarum PIC-NBN22（Pne-12）and fructo-oligosaccharides（FOS）on bowel movement and intestinal flora, healthy adults with a tendency toward constipation （stool frequency：3 to 5 times/week）a randomized, double-blind, crossover comparative study was conducted on 30 subjects（stratified analysis subjects：28 men（10 males, 18 females）, 45.6±2.1 years（mean ±standard error））. Results　A significant increase in the number of times of defecation at 2 weeks of ingestion（P ＜0.05）was observed by intake of the test food, and an increasing trend of Bifidobacterium in feces（P＜0.1）（next generation sequencing method）was confirmed. Conclusions　It was speculated that an increase in the intestinal Bifidobacterium is involved in the increase in the frequency of defecation due to the intake of the test food admitted in this study. Trial registration UMIN-CTR：UMIN000032411