薬理と治療

Abstract

Objectives　The aim of this study was to examine the effect of ingesting coffee chlorogenic acid（CGA）on skin temperature after cold water stress in healthy Japanese males. Methods　A randomized, double-blind, placebo-controlled, crossover intervention study was conducted on 24 healthy Japanese males who were cold-sensitive. A cold stress test（exposure to water temperature at 15℃ for 5 minutes）was performed on both hands after acclimating them in a 33℃ water bath for 30 minutes. Each subject ingested a test beverage（CGA-270 mg, CGA-135 mg or a placebo）45 minutes before the cold stress test with a one-week washout period between them. Skin temperature of the hands was measured before ingesting each beverage and at 2.5 minute intervals for 30 minutes immediately after the cold stress test. As an index of CGA efficacy, the recovery rate of skin temperature was calculated based on the skin temperature before and after the cold stress test. Results　Twenty-two subjects completed this study. The recovery rate of skin temperature after the cold stress test was significantly improved in subjects who ingested CGA-270 mg compared with the placebo（P＝0.003）. No significant difference was observed in subjects who ingested CGA-135 mg compared with the placebo. Conclusions　A single ingestion of CGA-270 mg improved skin temperature after a cold stress test in healthy Japanese males and CGA is expected to improve the QOL that was reduced by cold. This study is registered with UMIN Clinical Traials registry（ID：UMIN000029931）