薬理と治療

Abstract

Background/Objectives　In this study, we aimed to investigate the effects of ingestion of maltobionic acid（corn syrup containing maltobionic acid）on mineral absorption in healthy Japanese adult men and women. Methods　Thirty-five healthy Japanese adult men and women were tested through a randomized, double-blind, placebo-controlled, crossover study. They were allocated into three groups:Test food 1（corn syrup containing maltobionic acid 2 g, maltose syrup 2 g）; Test food 2 （corn syrup containing maltobionic acid 4 g）; Placebo food（maltose syrup 4 g）. Intestinal mineral absorption was assessed by calculating the change in the serum and urinary mineral content, and the percentage of retained minerals. Safety was assessed through physical examination and physician interviews. Here, we report comparisons between Test food 2 and Placebo food. Results　The final efficacy was assessed with a total of 29 subjects（16 males and 13 females）. The intake of maltobionic acid resulted in increased calcium and magnesium in the urine. Maltobionic acid seemed to efficiently carry out intestinal absorption（throughout the small intestine and large intestine）of minerals by maintaining the solubilization state of the minerals in the intestine, unlike the mineral absorption promotion effect that depends on large intestine fermentation. Conclusions　Thus, the intake of maltobionic acid may contribute to the efficient bioavailability of minerals by maintaining the solubilization of minerals while rapidly and persistently exerting mineral absorption promoting effects in the intestinal tract in healthy Japanese adult men and women. （UMIN-CTR ID: 000034976）