薬理と治療

Abstract

The chlorogenic acids had been reported as the polyphenols in coffee that decrease visceral fat. Therefore, that will effect to treat metabolic syndrome. Then, we made the chlorogenic acids-enriched ground coffee by specific roasting technique, and examined the efficacy in reducing visceral fat and the safety in healthy but obese volunteers. 　In this study, 48 healthy volunteers were divided into two groups by double blind method and each group took a cup of coffee every day that contained either low dose（0-50 mg）as control coffee group or high dose（270-330 mg）of chlorogenic acids as active coffee group for 12 weeks.　　Before and 12 weeks later of this study, biochemical blood tests and urine tests were examined. Every 4 weeks, anthropometry（BMI, visceral fat area and waist size）was measured. On every visit, healthy condition, meal analysis and major events in each 4 weeks was checked by medical staffs. As the results, in the high dose group, serum triglyceride decreased significantly after 12 weeks, and visceral fat area significantly decreased on 4th week and 12th week. 　　In the blood and urine examination, blood pressure, heart rate and subjective symptom did not show adverse effects.　　In conclusion, compared with control coffee, the chlorogenic acids︱enriched coffee was significantly effective and safe to decrease visceral fat and serum triglyceride.