薬理と治療

Abstract

Objective　Tomato-derived dietary fiber（TDF）is suggested to attenuate postprandial blood glucose elevation by suppressing or delaying absorption of glucose, but the patterns of effects were inconsistent between previous 2 studies. Here, we conducted an intervention study with a TDF-fortified test beverage to confirm the effect. We also analyzed the constituent sugars in TDF to clarify the qualitative characteristics. Methods　A placebo-controlled, crossover study was conducted. Placebo（P）and TDF-fortified beverage（T）were used. Fifty healthy subjects consumed either of the 2 beverages at immediately before eating 150 g of cooked rice. Blood glucose levels, maximum concentration of Δblood glucose levels （ΔCmax）, incremental area under the curve（IAUC）were compared between P and T group. Also, the constituent sugars in dietary fibers extracted from 7 tomato products and 5 other vegetables and fruit（carrot, petit vert, kale, red bell pepper, lemon）were analyzed by HPLC. Results　T suppressed blood glucose levels at 15, 30, and 45 min, ΔCmax, IAUC60 min, IAUC90 min, and IAUC120 min compared with P. The effects were clearer than that in the previous studies. The main constituent sugar in TDF was glucose, and it also contained xylose and mannose at a constant ratio. This was clearly different from the other dietary fibersʼsugar composition. Conclusions　The clinical study clearly shows the suppressive effects of TDF on postprandial blood glucose. Also, the constituent sugar composition of TDF is suggested to be distinctive compared with other vegetables/fruits-derived dietary fibers. （UMIN ID: UMIN000039601）