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A Study on the Effect of Food Containing Pine Bark Extract on Vascular Endothelial Function―A randomized, Double—blind, Placebo—controlled, Parallel—group Study―
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Abstract
Objectives A randomized, double-blind, placebo-controlled, parallel-group study was conducted to evaluate the effect of food containing pine bark extract(PBE)on vascular endothelial function in healthy subjects. Methods Forty healthy subjects with a body mass index(BMI)<30 were enrolled in the present study. The subjects were randomly divided into two groups and ingested either a food containing pine bark extract or a food without pine bark extract(placebo)for 8 weeks. Vascular endothelial function was evaluated by flow-mediated dilation(FMD)measured before, and at 4 and 8 weeks following ingestion. Results After 8 weeks, FMD improved significantly in the PBE group compared with the placebo group(P<0.05). Conclusions These results indicate that the food containing pine bark extract improves the vascular endothelial function in healthy subjects. (UMIN-CTR ID: UMIN000036602)
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