薬理と治療

Abstract

Objectives　Mulberry leaves have been used as feed for silkworms and consumed as a beverage or health food. This plant is characterized by containing immino-sugars. We evaluated effects of low dose immino-sugars on postprandial blood glucose levels. Methods　A randomized, placebo controlled, double-blind, crossover study was conducted for 22 healthy adult volunteers（10 males and 12 females aged from 21 to 64 years）with fasting blood glucose levels less than 126 mg/dL. Subjects consume either placebo or test food, followed by carbohydrate loading diet, and the levels of blood glucose and insulin were determined after 30-120 min. Results Intake of the test food significantly suppressed the elevation of postprandial blood glucose levels compared to that in the placebo group. The value at 30 min after the intake of test food（114.9±15.7 mg/dL）was significantly lower than that of placebo（128.2 ±15.7 mg╱dL, P＜0.01）. Total area under the curve of blood glucose level was 12,8385±1508 mg・min╱dL in the test group and 13,143±1742 mg・min╱dL in the placebo group（P＜0.01）. Conclusions　These results suggested that low dose immino-sugars had suppression effect on the elevation of postprandial blood glucose level.