薬理と治療

Abstract

Objectives　The aim of this study was to investigate the effect of oral intake of Amazake using the sake lees and rice koji on intenstinal microbiota on slight constipation patients. Methods　This randomized placebo-controlled crossover-group comparison study included 25 female adult slight constipation patients. Subjects were divided into 13 subjects who drink 125 mL of test beverage（Group Y）and 12subjects who drink 190 g of test beverage（Group A）. In each group, after ingestion of the test beverage or placebo for 30 days, the other beverage was ingested after a 14-days washout period. The feces were collected on the day before and on the last day of ingestion of each beverage, and changes in the intestinal flora due to ingestion were analyzed. Results　In group Y, no significant difference was observed after ingestion of test beverage compared with placebo, but in groupA, significant increase of Bifidobacterium was observed after ingestion of test beverage which include sake lees and rice koji compared with placebo. Conclusions　Ingestion of amazake beverages containing sake lees and rice koji increased the Bifidobacterium in the feces of subjects with slight constipation. Therefore, it is considered that an amazake beverage containing sake lees and rice koji has a function of improving human intestinal bacterial flora. （UMIN-CTR000038323）