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薬理と治療
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ピログルタミルテトラペプチド（pEPYP）含有食品の膝関節の自覚症状に及ぼす効果―ランダム化二重盲検プラセボ対照並行群間比較試験―
JPY
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ライフサイエンス出版
Abstract
Objectives The aim of this study was to investigate the effect of a dietary supplement containing pyroglutamyl tetrapeptide（pEPYP）on knee joint functions in healthy subjects with knee join pain and discomfort. Methods A total of 42 subjects were randomly divided into either pEPYP（15 mg/day）or placebo group. They orally consumed the respective test substance every day for 12 weeks. The knee joint functions including pain and discomfort were evaluated using JKOM（Japanese Knee Osteoarthritis Measure）and JOA（Japanese Orthopaedic Association）score. This study was registered in UMIN-CTR（ID: UMIN000035610）. Results Compared with the placebo group, pEPYP group showed a significant improvement in the pain score measured by JKOM at week 12（P＝0.048）. Conclusions These results suggested that the daily supplementation of pEPYP is effective for improving QOL in subjects with knee pain and discomfort.
