薬理と治療

Abstract

Objective　We investigated how adding kiwi fruit juice powder to a whey protein drink impacts blood amino acid levels and defecation status. Methods　This 2⊠2 randomized, placebo-controlled, double-blind, crossover trial included healthy Japanese subjects（n＝10）who consumed unspecified protein supplements and defecated 3-5 times a week. They were randomly divided into two groups（n＝5 per group）using a computerized random-number generator. One group consumed a protein drink including the kiwi fruit juice powder（KFJP consumption-period）; the other consumed a protein drink containing a placebo additive（Placebo consumption-period）. The subjects consumed their assigned drink daily over a two-week intervention period followed by a one-week washout period. Study outcomes included evaluation of blood amino acid levels and defecation status. Results　All 10 subjects completed the study. In the KFJP drink-period, the incremental area under the curve（IAUC）of total blood amino acids was significantly higher than the Placebo drink-period（P＜0.05）and a subgroup analysis revealed that the subjects having hard stools initially experienced a significant increase in stool volume two weeks after consuming the KFJP drink（P＜0.05）. No adverse events relating the test drinks were reported. Conclusions　A significant increase in the IAUC of total amino acids was observed for those who ingested whey protein containing kiwi fruit juice powder. Furthermore, subjects reporting hard stools initially, experienced a significant increase in stool volume after two weeks of consuming the whey protein drink containing kiwi fruit juice powder. Trial registration　UMIN-CTR: UMIN000039280 Foundation　NOF CORPORATION