薬理と治療

Abstract

Objective　The aim of this study was to evaluate the safety of long-term oral intake of passion fruit seeds extract on healthy subjects. Methods　An open-label study was conducted in 20 healthy subjects（20-64 years old）. The subjects were given the test product（125 mL drink containing 10 mg piceatannol derived from passion fruit seeds extract）3 times per day for 90 days. Physical examination, blood analysis, urinalysis, and a medical questionnaire were examined. Results　11 out of 20 subjects were included in the final analysis. No abnormal changes were observed in physical examination, blood analysis, or urinalysis. No adverse events attributed to the test drink were observed during the study. Conclusions　These results demonstrated that long-term oral intake of drink containing 30 mg piceatannol derived from passion fruit seeds extract was safe.（UMIN-CTR000039098）