薬理と治療

Abstract

Objective　This study aimed to assess benefit of a Lactobacillus paracasei subsp. paracasei NY1301-containing beverage on intestinal health. Methods　A randomized, placebo-controlled, double blind, parallel-group study was conducted in constipated subjects who consumed placebo（n＝49）or active food（containing 1×1011 cells of NY1301 daily）（n＝50）for 2 weeks after a 1-week pre-observation period. The changes in parameters of defecation and intestinal flora population were assessed. Results　Active food group had significantly higher lactobacillus occupancy among stool eubacteria than placebo group. The difference was found in all of the subject subpopulations stratified on basis of age and stool frequency. In addition, defecation frequency was significantly higher in younger subjects（aged 24-36）in active food group than the corresponding population in placebo group. There were no adverse events related to the investigational food intake. Conclusion　The intake of the L. paracasei subsp. paracasei NY1301 can benefit intestinal environment. （UMIN ID: UMIN000035202）