薬理と治療

Abstract

Objective　The aim of this study was to evaluate the effects of Amazake made from sake lees and rice koji on the sense of fatigue from daily activity in healthy adults.Methods　A randomized, double-blind, placebo-controlled, cross-over comparison study was conducted in 10 healthy female adults aged between 50 and 64. Each subject drank 112 kcal of Amazake or placebo drink every day for 2 weeks. At day 15, the subjects performed Uchida-Kraepelin performance test and bicycle ergometer cycling as mental and physical loadings. The sense of fatigue was evaluated using the visual analogue scales（VAS）, the profile of mood states （POMS）, and the Chalder fatigue scale（CFS）. Results　Based on the VAS score, Amazake ingestion significantly increased the sense of relief from fatigue caused by mental and physical loadings compared to the placebo ingestion. The POMS fatigue parameter and the CFS total scores tended to be lower after Amazake ingestion. In addition, persistence of interest and friendliness were significantly improved in the Amazake group. Conclusion　These results suggest that Amazake made from sake lees and rice koji could reduce the sense of fatigue caused by daily activities.（UMIN-CTR: UMIN000039610）