薬理と治療

Abstract

Objective　The objective of this study was to investigate the effects of intake of jelly compounded with 3,5-dihydroxy-4-methoxybenzyl alcohol（DHMBA）-containing supernatant extracted from soft tissue of the Pacific oyster（Crassostrea gigas）on perceptions of stress and sleep quality in healthy adult working men and women. Methods　Healthy adult working men and women（58 study subjects）experiencing stress from work or commuting were conducted a randomized, double-blind, placebo-controlled, comparative study. The study subjects were judged to be highly stressed by the brief job stress questionnaire（BJSQ）and rated as“slightly high/frequent”on the scales of “irritability”and “anxiety”in domain B（psychological and physical stress reactions）of the BJSQ. The study subjects took four packets of jelly compounded with DHMBA-containing supernatant extracted from soft tissue of C. gigas, or placebo jelly every day for 4 weeks. Jelly not containing oyster meat extract was used as a placebo. Perceptions of stress and sleep quality were evaluated using the BJSQ and the Oguri-Shirakawa-Azumi sleep inventory MA （OSA-MA） version, respectively, which were used as primary endpoints. The secondary endpoints were the scores of the profile of mood status 2nd edition-adult-short（POMS2-AS）. Results　From the BJSQ data, the change（improvement）in the score of“irritability”in domain B（psychological and physical stress reactions） from baseline to 2 weeks was significantly higher in the test-food group than in the placebo group（0.5±0.1 versus 0.1±0.1, P＝0.037）. In the OSA-MA, the change （improvement）in the score of the factor Ⅲ（frequent dreaming） from baseline to 4 weeks was significantly higher in the test-food group than in the placebo group（4.98±1.49 versus －1.26±2.39, P＝0.036）. There were no adverse events associated with the intake of jelly compounded with DHMBA︱containing supernatant extracted from soft tissue of C. gigas. Conclusions　Our results suggested that the intake of jelly compounded with DHMBA-con-taining supernatant extracted from soft tissue of C. gigas is effective in alleviating stress（irritability） in healthy adult working men and women, and in improving sleep quality in those who experience frequent dreaming. UMIN ID: UMIN000038468