薬理と治療

Abstract

Objective　Mulberry leaf containing 1-deoxynojirimycin（DNJ）is suggested to reduce postprandial blood glucose elevation by suppressing absorption of glucose. We conducted an intervention study with a food containing mulberry leaf powder to confirm the effect. Methods　A randomized, double-blind, placebo-controlled, crossover study was conducted in 30 healthy adult subjects with normal-high postprandial blood glucose level at 30 min（140-200 mg/dL）. They took 200 g of rice after ingesting of 100 mL water with test food containing 1.8 g of mulberry leaf powder （1.8 mg of DNJ）or placebo. The postprandial blood glucose level and insulin level were measured before and 30, 60, 90, 120 minutes after the intake of rice. Results　Ingestion of the test food containing mulberry leaf powder significantly reduced area under the curve（AUC（0-60 min））of blood glucose level, maximum concentration of blood glucose level（Cmax）and blood glucose level at 30 min compared with placebo. Conclusions　This study suggests that ingestion of mulberry leaf powder containing DNJ reduce the postprandial blood glucose level. （UMIN ID: UMIN000039508）