Full text loading...
薬理と治療
Abstract
Objective To verify the effects of 12 weeks of ingestion of fresh royal jelly on fatigue in Japanese women who felt tired and had difficulty in relieving fatigue. Methods An open-label, before-after trial was carried out from June to October 2019, and subjects of 49 healthy Japanese women aged 40 to 69 years were enrolled. Each capsule of fresh royal jelly contains 4.325 mg of 10-hydroxydecenoic acid. The subjects took four capsules once a day for 12 weeks. The primary outcome was subjective fatigue(visual analog scale), and the other outcomes were urinary 8-OHdG, simplified menopausal index, OSA sleep inventory MA version, subjective symptoms such as concentration, stiffness in the shoulder and dryness of the skin(Likert scale method), blood estradiol and free testosterone, and the lymphocyte /neutrophil ratio were assessed. Results The analysis set was an intention to treat, and 49 subjects(51.1±6.3 years old)were included in the analysis. The results of comparison before and after the taking of fresh royal jelly were as follows. The subjective fatigue as the primary outcome was significantly reduced. All secondary outcome measures except estradiol and lymphocyte/neutrophil ratio were significantly improved. Conclusions In healthy Japanese women aged 40 to 69 years old, intake of fresh royal jelly capsules for 12 weeks improved subjective symptoms related to fatigue, menopausal symptoms, and sleep. Trial registration UMIN000036665 Foundation MediProduce, Inc.
Data & Media loading...