薬理と治療

Abstract

Background　Face changes with age, and the wrinkles around eyes are common age-related symptoms. In this study, we examined the effect of a face lotion containing tranexamic acid, which has anti-inflammatory and whitening effects, on these facial wrinkles. Methods　The study was carried out with 13 healthy female subjects with age ranging between 30 and 59 years. They used Sparkle Whitening Mist Lotion, containing tranexamic acid（provided by Mʼz Science Corporation, Fukuoka, Japan）, only to one side of their faces twice a day for 4 weeks. Both sides of their faces were taken by the photo, and the wrinkles were evaluated by a single blind method, judged by the special inspectors according to the wrinkle grade established by Japanese Cosmetic Science Society. Skin condition of both side of their faces was also examined by the questionnaire. Results　The wrinkles only on the side of the faces using the face lotion containing tranexamic acid were significantly improved from the judgement by the special inspectors, while no significant changes were recognized on the other side of the faces. Statistical comparison of the changes in the wrinkle grade between the two sides of the faces also supports the improvement of the wrinkles around eyes by using the face wash. Moreover, result of the questionnaire indicated that almost all the subjects of this experiment realized the improvement effects in the skin condition, such as clarity, moisture, softness, and gloss. Conclusions　Significant effects of a face lotion containing tranexamic acid on the facial wrinkles around eyes and the improvement in the skin condition were statistically confirmed from the study.