薬理と治療

Abstract

※著者よりデータ提供者の要望のためとして当該論文の掲載撤回の申し出がありました。Objectives　We evaluated the effects of single intake of dietary supplements containing CLEAR BLACK GINGER（Kaempferia parviflora extract）on energy expenditure and metabolism among Japanese healthy adult males. Methods　We conducted a randomized, double-blind, placebo-controlled, crossover study. The subjects were 24 healthy adult males, and they were divided into two groups. The subjects took two capsules containing 75 mg of CLEAR BLACK GINGER （Kaempferia parviflora extract, total 150 mg）or placebo. Respiratory metabolism was measured at rest for 15 minutes in a sitting position and during exercise for 30 minutes using an ergometer（20 W, 60 rpm）. Energy expenditure was evaluated as the primary outcome. Results　Twenty-three subjects completed this study. Single oral intake of the dietary supplements containing CLEAR BLACK GINGER （Kaempferia parviflora extract）significantly increased the energy expenditure during exercise compared to the placebo based on the full analysis set. After excluding, the number of subjects analyzed was 16. The energy expenditure during exercise was significantly higher in the intake of the dietary supplements containing CLEAR BLACK GINGER（Kaempferia parviflora extract）than in the intake of placebo based on the per protocol set. Furthermore, the oxygen consumption and lipid oxidation during exercise were significantly higher and respiratory quotient during exercise were significantly lower in the intake of the dietary supplements containing CLEAR BLACK GINGER（Kaempferia parviflora extract）than in the intake of placebo. There was no significant difference on carbohydrate oxidation during exercise. Conclusion　Single intake of dietary supplements containing CLEAR BLACK GINGER （Kaempferia parviflora extract）increased the energy expenditure and the lipid oxidation during exercise, indicating that CLEAR BLACK GINGER（Kaempferia parviflora extract）promote energy expenditure and lipid metabolism in daily life. Thus, these findings demonstrate the utility of dietary supplements containing CLEAR BLACK GINGER（Kaempferia parviflora extract）as a functional food to assist in energy expenditure and lipid metabolism. （Clinical Trial Registration： UMIN 000045383）