薬理と治療

Abstract

Background　D-Allulose, a C-3 epimer of D-fructose, has been reported to enhance fat oxidation in healthy humans in the sitting position and during exercise. However, no studies have so far reported that D-allulose increases energy expenditure in healthy humans, although animal studies using Wistar and Sprague-Dawley rats have reported this finding. Energy metabolism has been reported to differ according to various postures in humans. Objectives　We examined the effects of a single dose of D-allulose on postprandial energy metabolism in the supine position in healthy humans. Methods　A randomized, single-blind, placebo-controlled crossover trial was conducted by including 6 healthy male and female volunteers. Overnight-fasted participants ingested a standardized breakfast for 30 min after taking 5 g D-allulose or 10 mg aspartame（not containing D-allulose）as a placebo, and subsequently energy metabolism in the supine position was evaluated by a breath-by-breath method using a respiratory gas analyzer. Results　In the D-allulose-treated group compared with the placebo group, the area under the curve of energy expenditure（20.6±1.1 vs. 19.9±0.9 kJ/4h/kg body weight（BW）, P＜0.05） and fat oxidation（14.8±1.2 vs. 13.0±1.4 kJ╱4h╱kg BW, P＜0.05） significantly increased, whereas that of carbohydrate oxidation slightly decreased but without a significant difference. Furthermore, there were no adverse effects in the D-allulose group. Conclusions　Ingestion of a single dose of 5 g D-allulose enhanced postprandial energy expenditure and fat oxidation in the supine position, suggesting that repeated intake of D-allulose may serve to prevent obesity in healthy humans. （UMIN Clinical Trials Registry ID: UMIN000016365）