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薬理と治療
Abstract
Objectives This study aimed to evaluate the efficacy of a supplement product containing salmon roe oil-derived DHA and EPA and deep-sea shark liver oil-derived DAGE on the sleep quality and stress in healthy adults who have difficulties sleeping and stress. Methods A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 80 participants(Age 20-64, Pittsburgh Sleep Quality Index≳6). Participants were randomly assigned to receive either the test product or placebo daily for 12 weeks. Daily intake of the test product contained salmon roe oil(DHA and EPA)and deep-sea shark liver oil (DAGE). Participants were assessed on their mood states and quality of sleep by sleep electroencephalogram measurement, Profile of Mood States 2nd Edition(POMS2), PSQI, Athens Insomnia Scale(AIS), International Physical Activity Questionnaire (IPAQ), and s-IgA secretion rate. Results The changes in the total time of non-REM sleep stage N1 and second sleep cycle at Week 12 were significantly lower in the test product group than in the placebo group. The proportion of non-REM sleep stage N3 and REM sleep stage R was significantly higher in the test product group than in the placebo group. In the participants group with POMS2 Vigor-Activity of less than 50, the daytime dysfunction by PSQI was significantly lower in the test product group than in the placebo group, Also, the POMS2 subscales of Depression -Dejection, Tension-Anxiety, Vigor-Activity, and Total Mood Disturbance were significantly lower in the test product group compared with the placebo group. Conclusions The increase in the proportion of non-REM sleep stage N3 and REM stage R suggests that the test product improves sleep quality. In addition, improvement of daytime sleepiness and anti-stress effect are expected in people with low vigor and activity. (UMIN ID: UMIN000041059)
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