薬理と治療

Abstract

Objectives　The purpose of this study was to investigate the effects of food consisting of rice bran fermented product containing HMPA on human abdominal fat in healthy adults. Methods　A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 30 healthy males（Aged 20-64, BMI 25 or more and less than 30）. Subjects were randomly assigned to receive either test food or placebo. Daily intake of the test food for 12 weeks. Subjects were assessed on abdominal fat area（primary outcome）, physical measurement, and safety assessment. Results　Abdominal fat area and subcutaneous fat area were significant lower in the test food group than in the placebo food group（P＜0.05）. During the study period, no adverse events attributable to the test food were observed. Conclusion　The study findings indicate that the food containing rice bran ferment have an effect of reducing abdominal fat in healthy men. （UMIN-CTR ID: UMIN000041225）