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フラバノール含有ココア摂取による皮膚血流と皮膚温度に及ぼす効果―ランダム化二重盲検プラセボ対照クロスオーバー比較試験―
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JPY
Abstract
Objective We evaluated the effects of cocoa on skin blood flow, skin temperature, and subjective measures in healthy adults. Methods A randomized, double-blind, placebo-controlled crossover comparison study was conducted in healthy subjects. After resting for at least 30 minutes at room temperature of 23± 1℃ and humidity of 40±5%, the subjects ingested a single dose of cocoa containing 30 mg of flavanols or placebo, which does not contain flavanols. Blood flow and skin temperature were measured every 10 minutes from 0 to 60 minutes after ingestion of the test food. Coldness of the hand was assessed by the visual analogue scale (VAS)scores every 20 minutes from 0 to 60 minutes after ingestion of the test food.Results In the analysis of 24 subjects, cocoa intake significantly increased skin blood flow, and skin temperature at 40 to 60 minutes after ingestion of the test food compared to placebo. The VAS analysis showed a significant improvement in“hand coldness”60 minutes after cocoa intake compared to placebo. Conclusions In healthy adults, the ingestion of cocoa containing 30 mg of flavanols significantly increased skin blood flow and skin temperature, and improved hand coldness by VAS score. (UMIN ID:UMIN000044542)
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