薬理と治療

Abstract

Objectives　We investigated the effects of continuous ingestion for 28 days of the supplement containing black ginger（Kaempferia parviflora）extract as a main ingredient, black pepper extract, black sesame extract, fermented black onion powder, and black soybean seed coat extract on cold intolerance. Methods　Fifty seven female volunteers with a subjective symptom of cold participated in a randomized, double-blind, placebo-controlled, parallel-group comparative study. Subjects consumed the test food containing black ginger extract, black pepper extract, black sesame extract, fermented black onion powder, and black soybean seed coat extract, or the placebo food for 28 days. The skin surface temperatures of fingertip and toe were measured by infrared thermography. The changes in sensation of cold whole body, cold limbs, shoulder stiffness, fatigue, quality of sleep, and defecation were evaluated by using subjective scale, visual analog scale（VAS）. Results　Continuous ingestion for 28 days of the supplement containing black ginger extract, black pepper extract, black sesame extract, fermented black onion powder, and black soybean seed coat extract significantly raised the toe skin surface temperature in subjects with low surface temperature and/or with a BMI of 22 or higher, and increased the fingertip skin surface temperature in subjects over 40 years old. Continuous feeding of the supplement reduced the VAS scales for cold limbs, fatigue, and defecation feeling. Conclusions　These results showed that continuous ingestion of the black ginger supplement improves cold intolerance, fatigue, and defecation feeling. （UMIN-CTR: UMIN000042764）